Tuesday, December 23, 2014
Profile

Dr Mazhar Iqbal

migondal@nibge.org


Principal Scientist


Work Phone: +92-41-2651475-79
Fax Phone: +92-41-2651472
Dr Mazhar Iqbal

Biography:

   1989 – 1991 M.Sc., University of The Punjab, Lahore.
   1992 – 1993 Asstt. Technical Officer, Delta Industries, (Pvt) Ltd., Lahore. 
   1993 – 1995 Research Trainee Fellow, NIBGE, Faisalabad.
   1995 – 2001 Senior Scientific Officer, NIBGE, Faisalabad.
   2001 – 2005 Ph.D. Organic Chemistry (Professor S.M. Roberts), The University of Liverpool, UK.
   2006 – 2007 Postdoctoral Research Fellow (Dr A.V. Stachulski), The University of Liverpool, UK.


Research Interests:

   Development of novel anti-viral drugs especially to treat Hepatitis B and C Viruses and the drug target identification of the potential compounds. Synthesis of Biologically Important Cyclopentenones.
Featuring:

  • Drug Discovery of anti-viral, anti-cancer and anti-parasitic agents 
  • Catalytic and stoichiometric organometallics as tools in organic synthesis
  • Cascade reactions, especially, conjugate addition-Peterson olefination reactions
  • Asymmetric synthesis of Natural products, especially Prostaglandins and Phytoprostanes
  • Acyl and arylglucuronides
  • Drug Target identifications 


Selected Publications: 

  • Hanif, M.; Khan, I.; Rama, N. H.; Noreen, S.; Choudhary, M. I.; Jones, P. G.; Iqbal, M. Synthesis, crystal structure and β-glucuronidase inhibition activity of some new hydrazinecarboxamides and their 1,2,4-triazole derivatives, Medicinal Chemistry Research, 2011, DOI 10.1007/s00044-011-9929-1. 
  • Stachulski, A. V.; Pidathala, C.; Row, E. C.; Sharma, R.; Berry, N. G.; Iqbal, M.; Bentley, J.; Allman, S. A.; Edward, G.; Helm, A.; Hellier, J.; Korba, B. E.; Semple, J. E.; Rossignol, J.-F. Thiazolides as Novel Antiviral Agents. II. Inhibition of Hepatitis C Virus Replication, Journal of Medicinal Chemistry, 2011, 54, 8670-8680.
  • Stachulski, A. V.; Pidathala, C.; Row, E. C.; Sharma, R.; Berry, N. G.; Iqbal, M.; Bentley, J.; Allman, S. A.; Edward, G.; Helm, A.; Hellier, J.; Korba, B. E.; Semple, J. E.; Rossignol, J.-F. Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication, Journal of Medicinal Chemistry, 2011, 54, 4119-4132.
  • Johnson, C. H.; Karlsson, E. S.; Sarda, S.; Iddon, L.; Iqbal, M.; Meng, X.; Harding, J. R.; Stachulski, A. V.; Nicholson, J. K.; Lindon, J. K.; Wilson, I. D.; Lindon, J. C. High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma, Rapid Communication in Mass Spectrometry, 2010, 24, 3043-3051.
  • Johnson, C. H.; Karlsson, E.; Sarda, S.; Iddon, L.; Iqbal, M.; Meng, X.; Harding, J. R.; Stachulski, A. V.; Nicholson, J. K.; Lindon, J. K.; Wilson, I. D.; Lindon, J. C. Integrated HPLC-MS and 1H NMR Spectroscopic Studies on Acyl Migration Reaction Kinetics of Model Drug Ester Glucuronides, Xenobiotica, 2010, 40, 9-23.
  • Johnson, C. H.; Karlsson, E. S.; Sarda, S.; Iddon, L.; Iqbal, M.; Meng, X.; Harding, J. R.; Stachulski, A. V.; Nicholson, J. K.; Lindon, J. K.; Wilson, I. D.; Lindon, J. C. High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma, Rapid Communication in Mass Spectrometry, 2010, 24, 3043-3051.
  • Berry,N. G.; Iddon, L.; Iqbal, M.; Meng, X.; Jayapal, J.; Stachulski, A. V.; Johnson, C. H.; Nicholson, J. K.; Lindon, J. C.; Harding, J. R.; Wilson, I. D. Structure-Reactivity Relationships for Arylacetic Acid 1β-O-Acyl Glucuronides: a Paradigm for Non-steroidal Anti-inflammatory Drug Metabolism, Organic & Biomolecular Chemistry, 2009,7, 2525-2533.
  • Rehman, M.; Anwar, M. A.; Iqbal, M; Akhtar, K.; Khalid, A. M.; Ghauri, M. A. Bioleaching of high grade Pb-Zn ore by mesophilic and moderately thermophilic iron and sulfur oxidizers, Hydrometallurgy, 2009, 97, 1-7.
  • Iqbal, M.; Duffy, P.; Cloughley, G.; Allan, B.; Lledo, A.; Verdaguer, X.; Riera, A.; Evans, P. The conjugate addition Peterson olefination reactions for the preparation of cross-conjugate cyclopentenone, PPAR-g ligands, Organic & Biomolecular Chemistry, 2008, 6, 4649-4661.
  • Iqbal, M.; Evans, P.; Lledo, A.; Verdaguer, X.; Pericàs, M. A.; Riera, A.; Krischke, M.; Sinha, A. K.; Mueller, M. J. Total Synthesis and Biological Activity of 13,14-Dehydro-12-Oxo-Phytodienoic Acids (Deoxy-J1-Phytoprostanes), ChemBioChem 2005, 6, 276-280.
  • Iqbal, M.; Li, Y.; Evans, P. Synthesis of Δ12,14-15-deoxy-PGJ1 methyl ester and epi-Δ12-15-deoxy-PGJ1
View Detail Vitae

   
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