Tuesday, April 30, 2024
Profile

Dr. Huma Tariq

huma.ncvi@gmail.com


Senior Scientist


Work Phone: +92 41 9201316-20 Ext. 3246
Fax Phone: +92 41 9201472

Qualification:

  • BS (Zoology), University of the Punjab. Lahore, Pakistan
  • M.Phil (Virology and Immunology), Atta ur Rehman School of Applied Biosciences, National University of Sciences and Technology ( NUST), Islamabad, Pakistan
  • Ph.D (Biological Sciences with specialization in Human Molecular Genetics),

 

Research Interests:

I am passionate to concentrate my future research on application of basic research to improve health and reduce burden of genetic disorders in Pakistani population. I have completed projects employing molecular biology and genetic techniques to achieve my research goals.

My PhD work was focused on molecular characterization of familial cases of neurological movement disorders from Pakistani families.  This work involved identification of patients, family recruitment, clinical profiling, and their genetic characterization using whole-exome sequencing. Different computational and functional studies were employed to validate the pathological status of the identified variants. Risk awareness and carrier testing information was provided to the participating families to reduce the occurrence of the disorder in future generations. My secondary research interest lies in virology and I developed an ELISA based in vitro infectivity assay for serum derived HCV genotype 3a of Pakistani population. This assay was helpful in screening serum samples with greater replication potential in cell culture. I taught lab technique modules to LUMS biology students, created recombinant DNA molecules for various applications and generated cell lines with stable and regulated expression of viral/regulatory proteins. I am also working of exploration of genetic aspects in human infertility and breast cancer cases.

My research work has been published in prestigious, peer reviewed international journals. Additionally, I contributed significantly in some interesting projects of human genetics which resulted in cutting edge findings to be published in the highly prestigious journal “Nature Genetics” and “Nature Communication”.

I am willing to develop an enthusiastic collaboration with a passionate team to bring health benefits to the people and improve the research culture in Pakistan. 

 

Research publications:

  1. Rubab M, Zain A, Mubeen B, Tariq H, Malik A, Arshad N. “Green Synthesized FM-AgNPs Lead to Alterations in Hematology, Oxidative Stress Biomarkers, and Microanatomy of Liver and Spleen in Rats” Brazilian archives of biology and technology (2023) 66(4)    (Impact factor 1.18) 
  2. Alkhayyat S, Khan M, Ahmad T, Haroon, Tariq H,  Baig M. “ A bibliometric analysis of the top 100 most cited papers and research trends in breast cancer related BRCA1 and BRCA2 genes” Medicine (2022) 101(38)   p e30576                                                 
  3. Tariq H, Tariq I, Bourinaris T, Houlden H & Naz S.Some pathogenic SETX variants are partially conserved during evolution” Gene.  (2021), 771: 145360          (Impact Factor 3.9) 
  4. Salpietro V, (12 others) Tariq H…..(upto 98 authors) and Houlden H. "AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders" Accepted in Nature Communication May 2019
  5. Tariq H, Butt JUR, Houlden H & Naz S.Are some C19orf12 variants monoallelic for neurological disorders?. Parkinsonism Relat Disord.  In press. doi: S1353-8020(19)30240-8 [pii]
  6. Cortese A, Simone R, Sullivan R, Vandrovcova J, Tariq H, Yan YW, Humphrey J, Jaunmuktane Z, Sivakumar P, Polke J & Ilyas M….. Houlden H “Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia”. Nature Genetics (2019) 51(4), 649-658                                         
  7. Mukhtar S, Imran R, Zaheer M, & Tariq H. “Frequency of non-motor symptoms in Parkinson's disease presenting to tertiary care centre in Pakistan: an observational, cross-sectional study”. BMJ Open (2018) 8(5), e019172                               
  8. Tariq H, Imran R, & Naz S. “A novel homozygous variant of SETX causes ataxia with oculomotor apraxia type 2”. Journal of Clinical Neurology (2018) 14(4), 498-504
  9. Tariq H, Mukhtar S, & Naz S. “A novel mutation in ALS2 associated with severe and progressive infantile onset of spastic paralysis. J Neurogenet (2017) 31(1-2), 26-29
  10. Tariq H & Naz S. “TFG associated hereditary spastic paraplegia: an addition to the phenotypic spectrum”. Neurogenetics (2017) 18(2), 105-109            
  11. Javed F, Manzoor S, Khattak A, Imran M, Pervez F, Ashraf J, Tariq H & Bhatti S. “Molecular characterization and florescence analysis of HCV NS3, NS3-4a and NS4a of genotype 3a”. Acta Virologica (2014) 59(3), 284-294                                                            
  12. Arshad N, Khan S, Tariq H & Samreen S. “Characterization of contact lens associated bacteria and their responses to botanical essential oils”. International Journal of Agriculture and Biology (2014) 16(6),1171-1176                                              
  13. Hussain T, Manzoor S, Waheed Y, Tariq H & Hanif K. “Phylogenetic analysis of Torque Teno Virus genome from Pakistani isolate and incidence of co-infection among HBV/HCV infected patients”. Virology Journal (2012) 9(1), 320                                               
  14. Tariq H, Manzoor S, Parvaiz F, Javed F, Fatima K, & Qadri I. “An overview: in vitro models of HCV replication in different cell cultures”. Infection Genetics and Evolution (2012) 12(1), 13-20                     
  15. Parvaiz F, Manzoor S, Tariq H, Javed F, Fatima K, & Qadri I. “Hepatitis C virus infection: molecular pathways to insulin resistance”. Virology Journal (2011) 8(1), 474
  16. Javed F, Manzoor S, Tariq H, Parvaiz F, Bilal M, Kanwal N.Amplification and Cloning of Entire Stuructural Genome (core-E2) of Hepatitis C Virus”. NUST Journal of Natural Sciences, (2012) 2(2), 33-37

   
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